Chemical profiling and in vitro biological properties of extracts containing rosmarinic acid, obtained from Thymus sp. and Rosmarinus sp. (Lamiaceae)

Title of the project: “Chemical profiling and in vitro biological properties of extracts containing rosmarinic acid, obtained from Thymus sp. and Rosmarinus sp. (Lamiaceae)”
Project acronym: RosThym

Approved budget: 246,950 RON

Project leader: Lecturer Irina IELCIU, PhD

Department of Pharmaceutical Botany, “Iuliu Haţieganu” University of Medicine and Pharmacy, 23 Gheorghe Marinescu, 3rd floor, 400337, Cluj-Napoca, Romania
E-mail: ;
BrainMap ID: U-1800-055D-9835

Mentor: Professor ILIOARA ELENA ONIGA, PhD
Department of Pharmacognosy, „Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă, 3rd floor, 400010, Cluj-Napoca, Romania
E-mail: ;
BrainMap ID: U-1700-038K-8191

Research project description:

Thymus marschallianus Willd. and Rosmarinus officinalis L. are two species of the Lamiaceae family which have proven important medicinal uses, that are reported to be due both to their content in polyphenolic compounds, especially in rosmarinic acid, a compound with remarkable pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial and antidiabetes. Diabetes mellitus is a metabolic disease having as a main symptom high sugar levels in blood and it can be categorized as one of the major diseases of modern world. The connection between all these becomes therefore important, and it appears necessary to study the properties of rosmarinic acid from the two species, its involvement in the pathways of the production of hyperglycemia and in reducing the oxidative stress caused by it. In this context, the present project proposes to determine the rosmarinic acid content of the two species and to evaluate the antioxidant activity and protective activity against glycemic stress, by preliminary in vitro techniques, followed by in vivo experimental research on animals with streptozotocin-induced diabetes. By all these, the present project proposes to provide scientific evidence on the fact that these species are valuable source of polyphenolic compounds, among which rosmarinic acid is the most prevalent and important for the protective activity against glycemic stress. To the best of our knowledge, there are few reported studies on the antidiabetic potential of Thymus and Rosmarinus species, but there are no reported data on the activity of T. marschallianus. Importance and relevance of the results obtained in this study is therefore related to the fact that they can be beneficial as there is an important need for the development of novel natural products with higher efficency and safer profile.